This multi-column distillation plant produces water for injection (WFI) for pharmaceutical applications . The principle: feed water is evaporated in several stages, and the vapor then condenses to form WFI . The plant is designed for consistent quality, reliable operation , and verifiable documentation .
 

 
 Application
 
 The distillation plant produces WFI quality for pharmaceutical applications, e.g.:
 
 
 
 Injection solutions
 
 
 Hemofiltration
 
 
 sterile cleaning
 
 
 The interpretation is based on the United States Pharmacopeia (USP) and the European Pharmacopoeia (Ph. Eur.) .
 

 
 This is how multi-column distillation works
 
 
 
 Pre-treated feedwater is evaporated in stages.
 
 
 The resulting steam condenses into WFI in the respective process stage.
 
 
 Special separation and droplet removal technologies (demisters) prevent droplets or impurities from entering the steam.
 
 
 The result is a controlled, traceable WFI generation with high process reliability .
 
 

 
 Hygiene design & validation
 
 The system is made of AISI 316L stainless steel (material 1.4404) with electropolished surfaces . This supports:
 
 
 
 GMP-compliant operation
 
 
 easy cleaning
 
 
 Validation in a regulated environment
 
 

 
 Automation & Process Monitoring
 
 Fully automated operation included:
 
 
 
 steering
 
 
 Data logging
 
 
 Alarm functions
 
 
 continuous quality monitoring (e.g. conductivity , pressure, temperature)
 
 

 
 Highlights
 
 
 
 Hygienic design in AISI 316L with highly polished surfaces
 
 
 Proven multi-column distillation process for a short ramp-up phase to the required quality with stable plant operation
 
 
 Validable documentation (DQ, IQ, OQ)
 
 
 Full automation including data logging and alarm management
 
 
 Droplet separation for high WFI quality
 
 
 Energy optimized through multiple evaporation/condensation stages and the use of preheaters
 
 
 Acceptance testing possible across a wide performance range
 
 

 
 Technical data
 
 Capacity: customized, typical range 300 – 11,000 l/h
 
 Material: AISI 316L (Material 1.4404)
 
 Method: Multi-column distillation (e.g., falling-film / multi-effect)
 
 Temperature range: Condensate approx. 85 – 95 °C in the last process step
 
 Conductivity (product water): < 1.3 µS/cm at 25 °C (WFI standard, depending on the input)
 
 TOC: < 500 ppb (according to pharmaceutical monograph)
 

 
 Options (depending on the version / project-specific)
 
 
 
 DQ / IQ / OQ
 
 
 simultaneous withdrawal of pure steam
 
 

 
 contact
 
 For information on design, qualification scope and integration into your PW/WFI infrastructure, please use the contact form below.
 

 
 Modular design & extensions
 
 Pharmaceutical CIP system – GMP/FDA CIP system
 
 Valve Block – Valve blocks
 
 Product preparation – manufacturing of liquid pharmaceuticals